Duke University Medical Center
103 Research Drive
433A MSRB I
Box 3156 DUMC
Durham, NC 27710
The primary interest of my research program is to better understand the biology of cancerous cells, including those of the brain and breast. As deregulated signal transduction pathways are a major signature of aggressive cancers, my research goals are:
Among the known signaling networks that are important for cancer formation, growth, and progression, three pathways have attracted much attention:
Given their significant involvement in various perspectives of cancer biology, these pathways are considered ideal targets for cancer therapeutics. However, monotherapy targeting these pathways has demonstrated limited success. It is, therefore, an urgent task to better understand these signaling pathways to improve their efficacy.