Bruce Alan Sullenger, PhD



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Professor of Surgery
Professor of Pharmacology and Cancer Biology
Associate Professor in Molecular Genetics and Microbiology
Director of the Duke Center for Translational Research
Department / Division:
Surgery / Surgical Sciences
1087 Msrb Ii
Box 103035
Durham, NC 27710
Office Telephone:
(919) 684-6413
  • PhD, Cornell University, 1990
Representative Publications:
  • Buddai, SK; Layzer, JM; Lu, G; Rusconi, CP; Sullenger, BA; Monroe, DM; Krishnaswamy, S. An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase. Journal of Biological Chemistry. 2010;285:5212-5223.  Abstract
  • Mi, J; Liu, Y; Rabbani, ZN; Yang, Z; Urban, JH; Sullenger, BA; Clary, BM. In vivo selection of tumor-targeting RNA motifs. Nature Chemical Biology. 2010;6:22-24.  Abstract
  • Wang, J; Wakeman, TP; Lathia, JD; Hjelmeland, AB; Wang, XF; White, RR; Rich, JN; Sullenger, BA. Notch promotes radioresistance of glioma stem cells. Stem Cells. 2010;28:17-28.  Abstract
  • Blake, CM; Sullenger, BA; Lawrence, DA; Fortenberry, YM. Antimetastatic potential of PAI-1-specific RNA aptamers. Oligonucleotides. 2009;19:117-128.  Abstract
  • Oney, S; Lam, RT; Bompiani, KM; Blake, CM; Quick, G; Heidel, JD; Liu, JY; Mack, BC; Davis, ME; Leong, KW; Sullenger, BA. Development of universal antidotes to control aptamer activity. Nature Medicine. 2009;15:1224-1228.  Abstract
  • Dollins, CM; Nair, S; Boczkowski, D; Lee, J; Layzer, JM; Gilboa, E; Sullenger, BA. Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. Chemistry and Biology. 2008;15:675-682.  Abstract
  • Long, SB; Long, MB; White, RR; Sullenger, BA. Crystal structure of an RNA aptamer bound to thrombin. RNA. 2008;14:2504-2512.  Abstract
  • Giangrande, PH; Zhang, J; Tanner, A; Eckhart, AD; Rempel, RE; Andrechek, ER; Layzer, JM; Keys, JR; Hagen, PO; Nevins, JR; Koch, WJ; Sullenger, BA. Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. Proceedings of the National Academy of Sciences of USA. 2007;104:12988-12993.  Abstract
  • Kierlin-Duncan, MN; Sullenger, BA. Using 5'-PTMs to repair mutant beta-globin transcripts. RNA. 2007;13:1317-1327.  Abstract
  • McNamara, JO; Andrechek, ER; Wang, Y; Viles, KD; Rempel, RE; Gilboa, E; Sullenger, BA; Giangrande, PH. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nature Biotechnology. 2006;24:1005-1015.  Abstract
  • Nimjee, SM; Keys, JR; Pitoc, GA; Quick, G; Rusconi, CP; Sullenger, BA. A novel antidote-controlled anticoagulant reduces thrombin generation and inflammation and improves cardiac function in cardiopulmonary bypass surgery. Molecular Therapy. 2006;14:408-415.  Abstract
  • Jones, JP; Kierlin, MN; Coon, RG; Perutka, J; Lambowitz, AM; Sullenger, BA. Retargeting mobile group II introns to repair mutant genes. Molecular Therapy. 2005;11:687-694.  Abstract
  • Nimjee, SM; Rusconi, CP; Sullenger, BA. Aptamers: an emerging class of therapeutics. Annual Review of Medicine. 2005;56:555-583.  Abstract
  • Layzer, JM; McCaffrey, AP; Tanner, AK; Huang, Z; Kay, MA; Sullenger, BA. In vivo activity of nuclease-resistant siRNAs. RNA. 2004;10:766-771.  Abstract
  • Rusconi, CP; Roberts, JD; Pitoc, GA; Nimjee, SM; White, RR; Quick, G; Scardino, E; Fay, WP; Sullenger, BA. Antidote-mediated control of an anticoagulant aptamer in vivo. Nature Biotechnology. 2004;22:1423-1428.  Abstract
  • Byun, J; Lan, N; Long, M; Sullenger, BA. Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes. RNA. 2003;9:1254-1263.  Abstract
  • White, RR; Shan, S; Rusconi, CP; Shetty, G; Dewhirst, MW; Kontos, CD; Sullenger, BA. Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2. Proceedings of the National Academy of Sciences of USA. 2003;100:5028-5033.  Abstract
  • Martell, RE; Nevins, JR; Sullenger, BA. Optimizing aptamer activity for gene therapy applications using expression cassette SELEX. Molecular Therapy. 2002;6:30-34.  Abstract
  • Rogers, CS; Vanoye, CG; Sullenger, BA; George, AL. Functional repair of a mutant chloride channel using a trans-splicing ribozyme. Journal of Clinical Investigation. 2002;110:1783-1789.  Abstract
  • Rusconi, CP; Scardino, E; Layzer, J; Pitoc, GA; Ortel, TL; Monroe, D; Sullenger, BA. RNA aptamers as reversible antagonists of coagulation factor IXa. Nature. 2002;419:90-94.  Abstract
  • Sullenger, BA; Gilboa, E. Emerging clinical applications of RNA. Nature. 2002;418:252-258.  Abstract
  • Lan, N; Rooney, BL; Lee, SW; Howrey, RP; Smith, CA; Sullenger, BA. Enhancing RNA repair efficiency by combining trans-splicing ribozymes that recognize different accessible sites on a target RNA. Molecular Therapy. 2000;2:245-255.  Abstract
  • Rusconi, CP; Yeh, A; Lyerly, HK; Lawson, JH; Sullenger, BA. Blocking the initiation of coagulation by RNA aptamers to factor VIIa. Thrombosis and Haemostasis. 2000;84:841-848.  Abstract
  • Sullenger, BA. Series introduction: emerging clinical applications of nucleic acids. Journal of Clinical Investigation. 2000;106:921-922.  Abstract
  • Watanabe, T; Sullenger, BA. Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts. Proceedings of the National Academy of Sciences of USA. 2000;97:8490-8494.  Abstract
  • Watanabe, T; Sullenger, BA. RNA repair: a novel approach to gene therapy. Advanced Drug Delivery Reviews. 2000;44:109-118.  Abstract
  • White, RR; Sullenger, BA; Rusconi, CP. Developing aptamers into therapeutics. Journal of Clinical Investigation. 2000;106:929-934.  Abstract
  • Long, MB; Sullenger, BA. Evaluating group I intron catalytic efficiency in mammalian cells. Molecular and Cellular Biology. 1999;19:6479-6487.  Abstract
  • Sullenger, BA. RNA repair as a novel approach to genetic therapy. Gene Therapy (Basingstoke). 1999;6:461-462.  Abstract
  • Zarrinkar, PP; Sullenger, BA. Optimizing the substrate specificity of a group I intron ribozyme. Biochemistry. 1999;38:3426-3432.  Abstract
  • Lan, N; Howrey, RP; Lee, SW; Smith, CA; Sullenger, BA. Ribozyme-mediated repair of sickle beta-globin mRNAs in erythrocyte precursors. Science. 1998;280:1593-1596.  Abstract
  • Zarrinkar, PP; Sullenger, BA. Probing the interplay between the two steps of group I intron splicing: competition of exogenous guanosine with omega G. Biochemistry. 1998;37:18056-18063.  Abstract
  • Jones, JT; Lee, SW; Sullenger, BA. Trans-splicing reactions by ribozymes. Methods in Molecular Biology. 1997;74:341-348.  Abstract
  • Jones, JT; Sullenger, BA. Evaluating and enhancing ribozyme reaction efficiency in mammalian cells. Nature Biotechnology. 1997;15:902-905.  Abstract
  • Lee, SW; Sullenger, BA. Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nature Biotechnology. 1997;15:41-45.  Abstract
  • Ishizaki, J; Nevins, JR; Sullenger, BA. Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. Nature Medicine. 1996;2:1386-1389.  Abstract
  • Jones, JT; Lee, SW; Sullenger, BA. Tagging ribozyme reaction sites to follow trans-splicing in mammalian cells. Nature Medicine. 1996;2:643-648.  Abstract
  • Lee, SW; Sullenger, BA. Isolation of a nuclease-resistant decoy RNA that selectively blocks autoantibody binding to insulin receptors on human lymphocytes. Journal of Experimental Medicine. 1996;184:315-324.  Abstract
  • Sullenger, BA. Ribozyme-mediated repair of RNAs encoding mutant tumor suppressors. Cytokines and Molecular Therapy. 1996;2:201-205.  Abstract
  • Campbell, TB; Sullenger, BA. Alternative approaches for the application of ribozymes as gene therapies for retroviral infections. Advances in Pharmacology. 1995;33:143-178.  Abstract
  • Doudna, JA; Cech, TR; Sullenger, BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of USA. 1995;92:2355-2359.  Abstract
  • Smith, C; Sullenger, BA. AIDS and HIV infection. Molecular and cell biology of human diseases series. 1995;5:195-236.  Abstract
  • Sullenger, BA. Colocalizing ribozymes with substrate RNAs to increase their efficacy as gene inhibitors. Applied Biochemistry and Biotechnology. 1995;54:57-61.  Abstract
  • Sullenger, BA. Revising messages traveling along the cellular information superhighway. Chemistry and Biology. 1995;2:249-253.  Abstract
  • Sullenger, BA; Cech, TR. Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing. Nature. 1994;371:619-622.  Abstract
  • Sullenger, BA; Cech, TR. Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science. 1993;262:1566-1569.  Abstract
  • Lee, TC; Sullenger, BA; Gallardo, HF; Ungers, GE; Gilboa, E. Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. The New biologist. 1992;4:66-74.  Abstract
  • Sullenger, BA; Gallardo, HF; Ungers, GE; Gilboa, E. Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation. Journal of Virology. 1991;65:6811-6816.  Abstract
  • Sullenger, BA; Gallardo, HF; Ungers, GE; Gilboa, E. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell. 1990;63:601-608.  Abstract
  • Sullenger, BA; Lee, TC; Smith, CA; Ungers, GE; Gilboa, E. Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication. Molecular and Cellular Biology. 1990;10:6512-6523.  Abstract
  • Hantzopoulos, PA; Sullenger, BA; Ungers, G; Gilboa, E. Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector. Proceedings of the National Academy of Sciences of USA. 1989;86:3519-3523.  Abstract